NADPH Oxidases and Their Role in Atherosclerosis
نویسندگان
چکیده
منابع مشابه
NADPH oxidases and atherosclerosis: unraveling the details.
NADPH OXIDASE (NOX)-mediated generation of reactive oxygen species (ROS) was first described in phagocytic cells, and for many years it was assumed that the primary role of NADPH oxidase activation was bacteriocidal; phagocytes generated a burst of ROS following activation. More recently, it has become clear that not only do multiple homologous NADPH oxidase subunits exist but that the expressi...
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Atherosclerosis is a complex disease that remains a leading cause of death and disability. The formation of vascular plaques arises from the interaction of dyslipidemia with the altered function of blood vessels and immune cells. The exact cause of atherosclerosis is not known, but from the 1950s onward, oxidative modifications of lipids and proteins were detected in vascular lesions, and the d...
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Megakaryocytes (MKs) undergo an endomitotic cell cycle, leading to polyploidy. We examined the expression of the flavoproteins and oxidative stress-promoting enzymes, NADPH oxidases (Nox’s), in MKs because of their known role in promoting the cell cycle. Although the expression of Nox isoforms varies between cell types, they are induced at the mRNA level by mitogenic stimuli. Western blotting o...
متن کاملDifferential expression of NADPH oxidases in megakaryocytes and their role in polyploidy.
Megakaryocytes (MKs) undergo an endomitotic cell cycle, leading to polyploidy. We examined the expression of the flavoproteins and oxidative stress-promoting enzymes, NADPH oxidases (Nox's), in MKs because of their known role in promoting the cell cycle. Although the expression of Nox isoforms varies between cell types, they are induced at the mRNA level by mitogenic stimuli. Western blotting o...
متن کاملNADPH Oxidases in Innate Immunity
and Duox in the respiratory epithelium. The location of these ROS-generating enzymes in the barrier tissues has prompted the expectation of their participation in host defense against invading pathogens in these tissues. Indeed, recent studies have begun to support this expectation, demonstrating roles in bacterial killing, cytokine production, apoptosis, gene expression and signaling, includin...
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ژورنال
عنوان ژورنال: Biomedicines
سال: 2020
ISSN: 2227-9059
DOI: 10.3390/biomedicines8070206